{"id":2182,"date":"2024-08-27T00:04:00","date_gmt":"2024-08-26T15:04:00","guid":{"rendered":"https:\/\/happytest.shop\/?p=2182"},"modified":"2024-12-01T00:05:22","modified_gmt":"2024-11-30T15:05:22","slug":"aptamers-revolutionizing-drug-testing-with-precision-and-flexibility","status":"publish","type":"post","link":"https:\/\/happytest.shop\/ja\/information\/aptamers-revolutionizing-drug-testing-with-precision-and-flexibility\/","title":{"rendered":"\u30a2\u30d7\u30bf\u30de\u30fc: \u7cbe\u5ea6\u3068\u67d4\u8edf\u6027\u3067\u85ac\u7269\u691c\u67fb\u306b\u9769\u547d\u3092\u8d77\u3053\u3059"},"content":{"rendered":"

\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u5206\u5b50\u8a8d\u8b58\u306e\u5206\u91ce\u3067\u753b\u671f\u7684\u306a\u6280\u8853\u3068\u3057\u3066\u767b\u5834\u3057\u3001\u85ac\u7269\u691c\u67fb\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u7528\u9014\u3067\u5f93\u6765\u306e\u6297\u4f53\u306b\u4ee3\u308f\u308b\u591a\u7528\u9014\u3067\u52b9\u679c\u7684\u306a\u4ee3\u66ff\u624b\u6bb5\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u4e16\u754c\u3092\u8a73\u3057\u304f\u8abf\u3079\u3001\u305d\u306e\u91cd\u8981\u6027\u3001\u4ed5\u7d44\u307f\u3001\u7279\u306b\u8907\u96d1\u306a\u6df7\u5408\u7269\u4e2d\u306e\u7269\u8cea\u306e\u691c\u51fa\u3068\u5206\u6790\u306b\u304a\u3051\u308b\u5229\u70b9\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a2\u30d7\u30bf\u30de\u30fc\u3068\u306f\u4f55\u3067\u3059\u304b?<\/h2>\n\n\n\n

\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u3001\u9ad8\u3044\u89aa\u548c\u6027\u3068\u7279\u7570\u6027\u3067\u7279\u5b9a\u306e\u6a19\u7684\u5206\u5b50\u306b\u7d50\u5408\u3067\u304d\u308b\u77ed\u3044\u4e00\u672c\u9396 DNA \u307e\u305f\u306f RNA \u5206\u5b50\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u5927\u898f\u6a21\u306a\u6838\u9178\u914d\u5217\u306e\u30d7\u30fc\u30eb\u304b\u3089\u6a19\u7684\u306b\u7d50\u5408\u3059\u308b\u5206\u5b50\u3092\u7e70\u308a\u8fd4\u3057\u9078\u629e\u3059\u308b\u3001\u6307\u6570\u95a2\u6570\u7684\u6fc3\u7e2e\u306b\u3088\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u7cfb\u7d71\u7684\u9032\u5316 (SELEX) \u3068\u547c\u3070\u308c\u308b\u30d7\u30ed\u30bb\u30b9\u3092\u901a\u3058\u3066\u5408\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u85ac\u7269\u691c\u67fb\u306b\u304a\u3051\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u5f79\u5272<\/h2>\n\n\n\n

\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u3001\u5c0f\u3055\u306a\u85ac\u7269\u5206\u5b50\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u3055\u3089\u306b\u306f\u7d30\u80de\u3092\u542b\u3080\u5e45\u5e83\u3044\u5206\u5b50\u306b\u72ec\u81ea\u306b\u7d50\u5408\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u305f\u3081\u3001\u85ac\u7269\u691c\u67fb\u306b\u7279\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u3053\u306e\u6a5f\u80fd\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u691c\u67fb\u65b9\u6cd5\u3067\u306f\u4e0d\u5341\u5206\u306a\u74b0\u5883\u3067\u975e\u5e38\u306b\u52b9\u679c\u7684\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a2\u30d7\u30bf\u30de\u30fc\u30d9\u30fc\u30b9\u306e\u30a2\u30c3\u30bb\u30a4\u306e\u5229\u70b9<\/h2>\n\n\n\n
    \n
  1. \u9ad8\u3044\u7279\u7570\u6027\u3068\u611f\u5ea6<\/strong>\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u3001\u9ad8\u3044\u7279\u7570\u6027\u3067\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u7d50\u5408\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3067\u304d\u308b\u305f\u3081\u3001\u6297\u4f53\u306a\u3069\u306e\u4ed6\u306e\u30d0\u30a4\u30aa\u53d7\u5bb9\u4f53\u3067\u3088\u304f\u898b\u3089\u308c\u308b\u4ea4\u5dee\u53cd\u5fdc\u3084\u507d\u967d\u6027\u306e\u53ef\u80fd\u6027\u304c\u4f4e\u6e1b\u3057\u307e\u3059\u3002<\/li>\n\n\n\n
  2. \u5b89\u5b9a\u6027\u3068\u6c4e\u7528\u6027<\/strong>: \u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306f\u7570\u306a\u308a\u3001\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u9ad8\u6e29\u3067\u3082\u5909\u6027\u305b\u305a\u3001\u3055\u307e\u3056\u307e\u306a\u74b0\u5883\u6761\u4ef6\u3067\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u5b98\u80fd\u57fa\u3067\u7c21\u5358\u306b\u4fee\u98fe\u3057\u3066\u3001\u5b89\u5b9a\u6027\u3068\u7d50\u5408\u7279\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n
  3. \u30b3\u30b9\u30c8\u52b9\u7387<\/strong>\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u958b\u767a\u3055\u308c\u308b\u3068\u3001\u6297\u4f53\u306e\u88fd\u9020\u306b\u6bd4\u3079\u3066\u4f4e\u30b3\u30b9\u30c8\u3067\u5927\u898f\u6a21\u306b\u5408\u6210\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u30d0\u30c3\u30c1\u9593\u306e\u5909\u52d5\u304c\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u308b\u305f\u3081\u3001\u4e00\u8cab\u3057\u305f\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u4fdd\u8a3c\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n
  4. \u8fc5\u901f\u306a\u7d50\u679c<\/strong>\u6bd4\u8272\u30c6\u30b9\u30c8\u306a\u3069\u306e\u30a2\u30d7\u30bf\u30de\u30fc\u30d9\u30fc\u30b9\u306e\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u6570\u79d2\u4ee5\u5185\u306b\u7d50\u679c\u3092\u751f\u6210\u3057\u3001\u91cd\u8981\u306a\u72b6\u6cc1\u3067\u5fc5\u8981\u306a\u5373\u6642\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/li>\n\n\n\n
  5. \u6700\u4f4e\u9650\u5fc5\u8981\u306a\u6a5f\u5668<\/strong>\u591a\u304f\u306e\u30a2\u30d7\u30bf\u30de\u30fc\u30a2\u30c3\u30bb\u30a4\u306f\u7279\u5225\u306a\u6a5f\u5668\u3092\u5fc5\u8981\u3068\u305b\u305a\u3001\u73fe\u5834\u3067\u5b9f\u65bd\u3067\u304d\u308b\u305f\u3081\u3001\u73fe\u5834\u3067\u306e\u30c6\u30b9\u30c8\u306b\u6700\u9069\u3067\u3059\u3002<\/li>\n<\/ol>\n\n\n\n

    \u85ac\u7269\u691c\u67fb\u306b\u304a\u3051\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u5fdc\u7528<\/h2>\n\n\n\n

    \u30a2\u30d7\u30bf\u30de\u30fc\u306f\u3001\u96fb\u6c17\u5316\u5b66\u3001\u5149\u5b66\u3001\u6bd4\u8272\u30bb\u30f3\u30b5\u30fc\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u5f62\u5f0f\u306e\u30a2\u30c3\u30bb\u30a4\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6700\u8fd1\u306e\u958b\u767a\u306b\u3088\u308a\u3001\u30d8\u30ed\u30a4\u30f3\u3084\u30d5\u30a7\u30f3\u30bf\u30cb\u30eb\u306a\u3069\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u3092\u3001\u975e\u5e38\u306b\u4e0d\u7d14\u7269\u304c\u6df7\u5165\u3057\u305f\u30b9\u30c8\u30ea\u30fc\u30c8 \u30c9\u30e9\u30c3\u30b0\u3067\u3082\u691c\u51fa\u3067\u304d\u308b\u30a2\u30d7\u30bf\u30de\u30fc \u30d9\u30fc\u30b9\u306e\u30bb\u30f3\u30b5\u30fc\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u7269\u3092\u4e00\u822c\u7684\u306a\u5e72\u6e09\u7269\u8cea\u3068\u533a\u5225\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30ab\u30c3\u30c8\u5264\u3084\u305d\u306e\u4ed6\u306e\u6dfb\u52a0\u7269\u306e\u5b58\u5728\u306b\u3088\u308a\u8aa4\u3063\u305f\u8aad\u307f\u53d6\u308a\u7d50\u679c\u304c\u51fa\u308b\u3053\u3068\u304c\u591a\u3044\u5f93\u6765\u306e\u65b9\u6cd5\u306b\u6bd4\u3079\u3066\u5927\u304d\u306a\u9032\u6b69\u3067\u3059\u3002<\/p>\n\n\n\n

    \u85ac\u7269\u691c\u51fa\u306b\u304a\u3051\u308b\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u5c06\u6765<\/h2>\n\n\n\n

    \u30a2\u30d7\u30bf\u30de\u30fc\u306e\u67d4\u8edf\u6027\u3068\u6709\u52b9\u6027\u306f\u3001\u85ac\u7269\u691c\u67fb\u3001\u7279\u306b\u8fc5\u901f\u3067\u6b63\u78ba\u306a\u7d50\u679c\u304c\u6c42\u3081\u3089\u308c\u308b\u74b0\u5883\u306b\u304a\u3044\u3066\u3001\u660e\u308b\u3044\u672a\u6765\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u53ef\u80fd\u6027\u306f\u5358\u306a\u308b\u85ac\u7269\u306e\u8b58\u5225\u306b\u3068\u3069\u307e\u308a\u307e\u305b\u3093\u3002\u4f53\u5185\u306e\u85ac\u7269\u6fc3\u5ea6\u306b\u95a2\u3059\u308b\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u85ac\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3084\u500b\u5225\u5316\u533b\u7642\u306b\u3082\u6d3b\u7528\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

    \u7d50\u8ad6<\/h2>\n\n\n\n

    \u85ac\u7269\u691c\u67fb\u306e\u8ab2\u984c\u306f\u3001\u85ac\u7269\u88fd\u5264\u306e\u8907\u96d1\u3055\u304c\u5897\u3057\u3001\u73fe\u5834\u3067\u306e\u8fc5\u901f\u306a\u691c\u67fb\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u306e\u5fc5\u8981\u6027\u304c\u9ad8\u307e\u308b\u306b\u3064\u308c\u3066\u9032\u5316\u3057\u7d9a\u3051\u3066\u3044\u307e\u3059\u304c\u3001\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u975e\u5e38\u306b\u6709\u671b\u306a\u6280\u8853\u3068\u3057\u3066\u969b\u7acb\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u30e6\u30cb\u30fc\u30af\u306a\u7279\u6027\u306f\u3001\u6b63\u78ba\u306a\u691c\u51fa\u3092\u4fdd\u8a3c\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u3088\u308a\u6d17\u7df4\u3055\u308c\u305f\u4f7f\u3044\u3084\u3059\u3044\u691c\u67fb\u30ad\u30c3\u30c8\u306e\u958b\u767a\u3078\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3082\u958b\u304d\u307e\u3059\u3002\u7d99\u7d9a\u7684\u306a\u7814\u7a76\u958b\u767a\u306b\u3088\u308a\u3001\u30a2\u30d7\u30bf\u30de\u30fc\u306f\u3059\u3050\u306b\u4e16\u754c\u4e2d\u306e\u85ac\u7269\u691c\u67fb\u306e\u6a19\u6e96\u3068\u306a\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u5206\u91ce\u3067\u5b89\u5168\u6027\u3068\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306e\u3088\u308a\u4fe1\u983c\u6027\u304c\u9ad8\u304f\u52b9\u7387\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    \u5b66\u8853\u53c2\u8003\u6587\u732e<\/h3>\n\n\n\n
      \n
    1. Canoura, J., Alkhamis, O., Venzke, M., Ly, PT, & Xiao, Y. (2024). \u30a2\u30d7\u30bf\u30de\u30fc\u30d9\u30fc\u30b9\u306e\u6bd4\u8272\u30aa\u30d4\u30aa\u30a4\u30c9\u691c\u67fb\u306e\u958b\u767a\u3002\u00a0\u30b8\u30e3\u30c3\u30af\u30b9\u30fb\u30aa\u30fc<\/em>\u30014(3)\u30011059-1072\u3002 DOI: 10.1021\/jacsau.3c00801<\/li>\n\n\n\n
    2. Ellington, AD\u3001Szostak, JW (1990)\u3002\u300c\u7279\u5b9a\u306e\u30ea\u30ac\u30f3\u30c9\u306b\u7d50\u5408\u3059\u308bRNA\u5206\u5b50\u306ein vitro\u9078\u629e\u300d\u00a0\u81ea\u7136<\/em>, 346, 818-822.<\/li>\n\n\n\n
    3. Tuerk, C., & Gold, L. (1990)\u3002\u300c\u6307\u6570\u95a2\u6570\u7684\u6fc3\u7e2e\u306b\u3088\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u7cfb\u7d71\u7684\u9032\u5316\uff1a\u30d0\u30af\u30c6\u30ea\u30aa\u30d5\u30a1\u30fc\u30b8 T4 DNA \u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u5bfe\u3059\u308b RNA \u30ea\u30ac\u30f3\u30c9\u300d\u00a0\u79d1\u5b66<\/em>, 249, 505-510.<\/li>\n\n\n\n
    4. Stoltenburg, R., Reinemann, C., & Strehlitz, B. (2007). \u300cSELEX\u2014\u9ad8\u89aa\u548c\u6027\u6838\u9178\u30ea\u30ac\u30f3\u30c9\u3092\u751f\u6210\u3059\u308b\u9769\u65b0\u7684\u306a\u65b9\u6cd5\u300d\u00a0\u751f\u4f53\u5206\u5b50\u5de5\u5b66<\/em>, 24(4), 381-403.<\/li>\n<\/ol>\n\n\n\n

      \u3053\u308c\u3089\u306e\u53c2\u8003\u6587\u732e\u306f\u3001\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u80cc\u5f8c\u306b\u3042\u308b\u79d1\u5b66\u3068\u3001\u85ac\u7269\u691c\u67fb\u6280\u8853\u306b\u304a\u3051\u308b\u305d\u306e\u5909\u9769\u306e\u53ef\u80fd\u6027\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u5f37\u529b\u306a\u67a0\u7d44\u307f\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>","protected":false},"excerpt":{"rendered":"

      Aptamers are emerging as a groundbreaking technology in the field of molecular recognition, offering a versatile and effective alternative to traditional antibodies in various applications, including drug testing. This article delves into the world of aptamers, explaining their significance, how they work, and their advantages in detecting and analyzing substances, particularly in complex mixtures. What Are Aptamers? Aptamers are short, single-stranded DNA or RNA molecules that can bind to specific target molecules with high affinity and specificity. They are synthesized through a process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX), which involves repeatedly selecting molecules that bind to a target from a large pool of nucleic acid […]<\/p>","protected":false},"author":1,"featured_media":2185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"none","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"categories":[115],"tags":[116,120,117,121,119],"drug":[122],"location":[90],"class_list":["post-2182","post","type-post","status-publish","format-standard","has-post-thumbnail","category-information","tag-aptamers","tag-drug-monitoring","tag-drug-testing","tag-new-technology","tag-selex","drug-all","location-worldwide"],"acf":[],"_links":{"self":[{"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/posts\/2182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/comments?post=2182"}],"version-history":[{"count":0,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/posts\/2182\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/media\/2185"}],"wp:attachment":[{"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/media?parent=2182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/categories?post=2182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/tags?post=2182"},{"taxonomy":"drug","embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/drug?post=2182"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/happytest.shop\/ja\/wp-json\/wp\/v2\/location?post=2182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}